Natural Product Synthesis & Chemical Biology

Independent Work
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9. Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1
9. Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1
Y. Zhang*†, Y. Cao†, X. Wu, Z. Chen, B. Chen, A. Wang, Y. Guo, W. Chen, R. Xue, Z. Liu, Y. Li, T. Li, R. Cheng, N. Zhou, J. Li, Y. Liu, X. Zhao, H. Luo, M. Xu, H. Li*, Y. Geng*
Nat. Commun. 2024, 8936
2024-10-17
9. Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1
8. Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy
8. Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy
Hu Wang, Jiaxing Wang, Hao Cui, Chenyu Fan, Yuzhou Xue, Huiying Liu, Hui Li, Jianping Li, Houhua Li, Ying Sun, Wengong Wang, Jiangping Song, Changtao Jiang*, Ming Xu*
Nat. Metab. 2024, 6, 1161
2024-05-02
8. Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy
7. Enantioselective Divergent Syntheses of Diterpenoid Pyrones
7. Enantioselective Divergent Syntheses of Diterpenoid Pyrones
Yunpeng Ji, Yaqian Liu, Weiqiang Guan, Chuning Guo, Hongli Jia, Benke Hong, Houhua Li*
J. Am. Chem. Soc. 2024, 146, 9395–9403.
2024-03-19
7. Enantioselective Divergent Syntheses of Diterpenoid Pyrones
6. Enantioselective Synthesis of the 1,3-Dienyl-5-Alkyl-6-Oxy Motif: Method Development and Total Synthesis
6. Enantioselective Synthesis of the 1,3-Dienyl-5-Alkyl-6-Oxy Motif: Method Development and Total Synthesis
Jie Wang, Chuning Guo, Yaqian Liu, Yunpeng Ji, Hongli Jia, Houhua Li*
Angew. Chem. Int. Ed. 2024, 63, e202400478
2024-01-26
6. Enantioselective Synthesis of the 1,3-Dienyl-5-Alkyl-6-Oxy Motif: Method Development and Total Synthesis
5. Proline Uptake Promotes Activation of Lymphoid Tissue Inducer Cells to Maintain Gut Homeostasis
5. Proline Uptake Promotes Activation of Lymphoid Tissue Inducer Cells to Maintain Gut Homeostasis
D. Wu, Z. Li, Y. Zhang, Y. Zhang, G. Ren, Y. Zeng, H. Liu, W. Guan, X. Zhao, P. Li, L. Hu, Z. Hou, J. Gong, J. Li, W. Jin, Z. Hu, C. Jiang, H. Li, C. Zhong*
Nat. Metab. 2023, 5, 1953
2023-10-25
5. Proline Uptake Promotes Activation of Lymphoid Tissue Inducer Cells to Maintain Gut Homeostasis
4. FAM3A Deficiency-Induced Mitochondrial Dysfunction Underlies Post‑Infarct Mortality&Heart Failure
4. FAM3A Deficiency-Induced Mitochondrial Dysfunction Underlies Post‑Infarct Mortality&Heart Failure
Tan Xu, Jiaxing Wang, Xiaoxiao Liu, Rui Xiang, Houhua Li, Shiqiang Wang, Jichun Yang,* Ming Xu*
J. of Cardiovasc. Trans. Res. 2023, https://doi.org/10.1007/s12265-023-10382-w
2023-10-25
4. FAM3A Deficiency-Induced Mitochondrial Dysfunction Underlies Post‑Infarct Mortality&Heart Failure
3. Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin
3. Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin
Yunpeng Ji†, Benke Hong†(†co-first author), Ivan Franzoni, Mengyang Wang, Weiqiang Guan, Hongli Jia, Houhua Li*
Angew. Chem. Int. Ed. 2022, 61, e202116136 (Highlighted in Synfacts, Org. Chem. Highl.)
2022-02-10
3. Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin
2. Enantioselective Total Synthesis of Berkeleyone A and Preaustinoids
2. Enantioselective Total Synthesis of Berkeleyone A and Preaustinoids
Yang Zhang†, Yunpeng Ji†(†co-first author), Ivan Franzoni, Chuning Guo, Hongli Jia, Benke Hong, Houhua Li*
Angew. Chem. Int. Ed. 2021, 60, 14869 (Highlighted in Org. Chem. Highlights, Aug. 29, 2022)
2021-04-15
2. Enantioselective Total Synthesis of Berkeleyone A and Preaustinoids
1. Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids
1. Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids
Benke Hong, Weilong Liu, Jin Wang, Jinbao Wu, Yuichiro Kadonaga, Pei-Jun Cai, Hong-Xiang Lou, Zhi-Xiang Yu, Houhua Li,* Xiaoguang Lei,*
Chem 2019, 5, 1671-1681 (Highlighted in Chem 2019, 5, 1368-137)
2019-04-24
1. Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids
Before PKU
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25. Enantioselective Synthesis of Five-Membered-Ring Atropisomers with a Chiral Rh(III) Complex
25. Enantioselective Synthesis of Five-Membered-Ring Atropisomers with a Chiral Rh(III) Complex
Saad Shaaban, Houhua Li, Felix Otte, Carsten Strohmann, Andrey P. Antonchick*, and Herbert Waldmann*,
Org. Lett. 2020, 22, 9199-9202.
2020-11-13
25. Enantioselective Synthesis of Five-Membered-Ring Atropisomers with a Chiral Rh(III) Complex
24. Syntheses of Skeletally Diverse Tetracyclic Isodon Diterpenoid Scaffolds Guided by Dienyne...
24. Syntheses of Skeletally Diverse Tetracyclic Isodon Diterpenoid Scaffolds Guided by Dienyne...
Weilong Liu, Zongwei Yue, Zhen Wang, Houhua Li, Xiaoguang Lei*
Org. Lett. 2020, 22, 7991-7996.
2020-10-06
24. Syntheses of Skeletally Diverse Tetracyclic Isodon Diterpenoid Scaffolds Guided by Dienyne...
23. Enantioselective Formal C(sp3)−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone..
23. Enantioselective Formal C(sp3)−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone..
Houhua Li, Rajesh Gontla, Jana Flegel, Christian Merten, Slava Ziegler, Andrey P. Antonchick,* Herbert Waldmann*
Angew. Chem. Int. Ed. 2019, 58, 307-311.
2018-10-17
23. Enantioselective Formal C(sp3)−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone..
22. C−H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway..
22. C−H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway..
Gang Shan, Jana Flegel, Houhua Li, Christian Merten, Slava Ziegler, Andrey P. Antonchick,* Herbert Waldmann*
Angew. Chem. Int. Ed. 2018, 57, 14250-14254.
2018-09-11
22. C−H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway..
21. ent-Jungermannenone C Triggers Reactive Oxygen Species-Dependent Cell Differentiation...
21. ent-Jungermannenone C Triggers Reactive Oxygen Species-Dependent Cell Differentiation...
Zongwei Yue, Xinhua Xiao, Jinbao Wu, Xiaozhou Zhou, Weilong Liu, Yaxi Liu, Houhua Li, Guoqiang Chen, Yingli Wu,* Xiaoguang Lei*
J. Nat. Prod. 2018, 81, 298-306.
2018-02-02
21. ent-Jungermannenone C Triggers Reactive Oxygen Species-Dependent Cell Differentiation...
20. Fawcettimine-Type Lycopodium Alkaloids as a Driving Force for Discoveries in Organic Synthesis
20. Fawcettimine-Type Lycopodium Alkaloids as a Driving Force for Discoveries in Organic Synthesis
19. Divergent Total Syntheses of (−)-Huperzine Q, (+)-Lycopladine B, (+)-Lycopladine C, and...
19. Divergent Total Syntheses of (−)-Huperzine Q, (+)-Lycopladine B, (+)-Lycopladine C, and...
Benke Hong, Dachao Hu, Jinbao Wu, Jing Zhang, Houhua Li, Yingming Pan, Xiaoguang Lei*
Chem. Asian J. 2017, 12, 1557-1567 (Selected as a Very Important Paper).
2017-04-25
19. Divergent Total Syntheses of (−)-Huperzine Q, (+)-Lycopladine B, (+)-Lycopladine C, and...
18. Exploring Site Selectivity of Iridium Hydride Insertion into Allylic Alcohols: Serendipitous...
18. Exploring Site Selectivity of Iridium Hydride Insertion into Allylic Alcohols: Serendipitous...
Houhua Li†, Daniele Fiorito†(†co-first author), Clément Mazet*
ACS Catal. 2017, 7, 1554-1562.
2017-01-17
18. Exploring Site Selectivity of Iridium Hydride Insertion into Allylic Alcohols: Serendipitous...
17. Iridium-Catalyzed Selective Isomerization of Primary Allylic Alcohols
17. Iridium-Catalyzed Selective Isomerization of Primary Allylic Alcohols
Houhua Li, Clément Mazet*
Acc. Chem. Res. 2016, 49, 1232-1241.
2016-03-09
17. Iridium-Catalyzed Selective Isomerization of Primary Allylic Alcohols
16. Scalable Total Synthesis of rac-Jungermannenones B and C
16. Scalable Total Synthesis of rac-Jungermannenones B and C
Weilong Liu†, Houhua Li†(†co-first author), Peijun Cai, Zhen Wang, Zhi-Xiang Yu, Xiaoguang Lei*
Angew. Chem. Int. Ed. 2016, 55, 3112-3116 (Highlighted in Synfacts 2016, 12, 332).
2016-01-28
16. Scalable Total Synthesis of rac-Jungermannenones B and C
14. Pd2Au36(SR)24 cluster: structure studies†
14. Pd2Au36(SR)24 cluster: structure studies†
B. Zhang, S. Kaziz, H. Li, D. Wodka, S. Malola, O. Safonova, M. Nachtegaal, C. Mazet, I. Dolamic, J. Llorca, E. Kalenius, L. M. L. Daku, H. Hakkinen, T. Bürgi,* N. Barrabés*
Nanoscale 2015, 7, 17.
2015-09-22
14. Pd2Au36(SR)24 cluster: structure studies†
13. Enantioselective Total Synthesis of (−)-Incarviatone A
13. Enantioselective Total Synthesis of (−)-Incarviatone A
B. Hong, C. Li, Z. Wang, J. Chen, H. Li,* X. Lei*
J. Am. Chem. Soc. 2015, 137, 11946-11949.
2015-09-15
13. Enantioselective Total Synthesis of (−)-Incarviatone A
12. Catalyst-Directed Diastereoselective Isomerization of Allylic Alcohols for the Stereoselective..
12. Catalyst-Directed Diastereoselective Isomerization of Allylic Alcohols for the Stereoselective..
Houhua Li, Clément Mazet*
J. Am. Chem. Soc. 2015, 137, 10720-10727 (Highlighted in Synform 2016, A21-A24).
2015-08-03
12. Catalyst-Directed Diastereoselective Isomerization of Allylic Alcohols for the Stereoselective..
11. Modulation of Active Sites in Supported Au38(SC2H4Ph)24 Cluster Catalysts:...
11. Modulation of Active Sites in Supported Au38(SC2H4Ph)24 Cluster Catalysts:...
Bei Zhang, Sameh Kaziz, Houhua Li, Miguel González Hevia, Dawid Wodka, Clément Mazet, Thomas Bürgi,* Noelia Barrabés*, J. Phys. Chem. C 2015, 119, 11193-11199.
2015-03-20
11. Modulation of Active Sites in Supported Au38(SC2H4Ph)24 Cluster Catalysts:...
10. Total Syntheses of (−)-Huperzine Q and (+)-Lycopladines B and C
10. Total Syntheses of (−)-Huperzine Q and (+)-Lycopladines B and C
Benke Hong†, Houhua Li†(†co-first author), Jinbao Wu, Jing Zhang, Xiaoguang Lei*
Angew. Chem. Int. Ed. 2015, 54, 1011-1015.
2014-10-30
10. Total Syntheses of (−)-Huperzine Q and (+)-Lycopladines B and C
9. Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group...
9. Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group...
Jing Zhang, Jinbao Wu, Benke Hong, Wenying Ai, Xiaoming Wang, Houhua Li, Xiaoguang Lei*,
Nat. Commun. 2014, 5, 4614.
2014-08-01
9. Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group...
8. Well-defined transition metal hydrides in catalytic isomerizations
8. Well-defined transition metal hydrides in catalytic isomerizations
Evgeny Larionov, Houhua Li, Clément Mazet*
Chem. Commun. 2014, 50, 9816-9826.
2014-06-05
8. Well-defined transition metal hydrides in catalytic isomerizations
7. Steric Parameters in the Ir-Catalyzed Regio- and Diastereoselective Isomerization of Primary...
7. Steric Parameters in the Ir-Catalyzed Regio- and Diastereoselective Isomerization of Primary...
Houhua Li, Clément Mazet*
Org. Lett. 2013, 15, 6170-6173.
2013-11-12
7. Steric Parameters in the Ir-Catalyzed Regio- and Diastereoselective Isomerization of Primary...
5. Challenges and Strategies to the Total Syntheses of Fawcettimine-Type and Serratinine-Type...
5. Challenges and Strategies to the Total Syntheses of Fawcettimine-Type and Serratinine-Type...
Xiaoming Wang, Houhua Li, Xiaoguang Lei*
Synlett 2013, 24, 1032-1043 (Invited Synpacts Article).
2013-04-12
5. Challenges and Strategies to the Total Syntheses of Fawcettimine-Type and Serratinine-Type...
6. Collective Synthesis of Lycopodium Alkaloids and Tautomer Locking Strategy for the Total...
6. Collective Synthesis of Lycopodium Alkaloids and Tautomer Locking Strategy for the Total...
Houhua Li†, Xiaoming Wang†(†co-first author), Benke Hong, Xiaoguang Lei*
J. Org. Chem. 2013, 78, 800-821 (Selected as the Featured and Cover Article).
2012-09-13
6. Collective Synthesis of Lycopodium Alkaloids and Tautomer Locking Strategy for the Total...
4. Selective Alkene Metathesis in the Total Synthesis of Complex Natural Product
4. Selective Alkene Metathesis in the Total Synthesis of Complex Natural Product
Xiaogaung Lei*, Houhua Li
Stereoselective Alkene Synthesis (Ed. Jianbo Wang), Top. Curr. Chem. Springer-Verlag, Heidelberg, 2012, 327, 163-196.
2012-04-17
4. Selective Alkene Metathesis in the Total Synthesis of Complex Natural Product
3. Total Syntheses of Lycopodium Alkaloids (+)-Fawcettimine, (+)-Fawcettidine, and...i
3. Total Syntheses of Lycopodium Alkaloids (+)-Fawcettimine, (+)-Fawcettidine, and...i
Houhua Li, Xiaoming Wang, Xiaoguang Lei*
Angew. Chem. Int. Ed. 2012, 51, 491-495 (Highlighted in Chin. J. Org. Chem. 2012, 32, 639).
2011-11-23
3. Total Syntheses of Lycopodium Alkaloids (+)-Fawcettimine, (+)-Fawcettidine, and...i
2. Efficient Generation of ortho-Quinone Methide: Application to the Biomimetic Syntheses of ...f
2. Efficient Generation of ortho-Quinone Methide: Application to the Biomimetic Syntheses of ...f
Daohong Liao, Houhua Li, Xiaoguang Lei*
Org. Lett. 2012, 14, 18-21.
2011-11-02
2. Efficient Generation of ortho-Quinone Methide: Application to the Biomimetic Syntheses of ...f
1.Regio- and stereo-selective synthesis of aryl 2-deoxy-C-glycopyranosides by palladium-catalyzed...
1.Regio- and stereo-selective synthesis of aryl 2-deoxy-C-glycopyranosides by palladium-catalyzed...
Hou-Hua Li, Xin-Shan Ye*
Org. Biomol. Chem. 2009, 7, 3855-3861.
2009-07-20
1.Regio- and stereo-selective synthesis of aryl 2-deoxy-C-glycopyranosides by palladium-catalyzed...
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