10. Total Syntheses of (−)-Huperzine Q and (+)-Lycopladines B and C
Utilizing a late‐stage enamine bromofunctionalization strategy, the twelve‐step total synthesis of (−)‐huperzine Q was accomplished. Furthermore, the first total syntheses of (+)‐lycopladines B and C are described. An unprecedented X‐ray crystal structure of an unusual epoxyamine intermediate is also reported, and the synthetic application of this intermediate in natural product synthesis is demonstrated.