Natural Product Synthesis & Chemical Biology

2. Efficient Generation of ortho-Quinone Methide: Application to the Biomimetic Syntheses of ...f

41623e9c088c4de8ba87280a81d1f043.gif

An efficient method using silver oxide-mediated oxidation for the synthesis of ortho-quinone methides has been developed and applied to the biomimetic syntheses of novel trimeric natural products, (±)-schefflone and tocopherol trimers. Further studies of the critical trimerization as well as substrate scope and limitations are also reported.

Address: 38 Xueyuan Rd, Haidian Distrcit, Beijing, 100191, China  

Email:Lihouhua@pku.edu.cn
Tel:+86 010-82805512